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Sulzer lab publications
Selected references from our lab listed by area of interest.


go to an area of interest:
Presynaptic regulation of neurotransmitter release
Physiology of midbrain dopamine neurons
Psychostimulant and addictive drugs: mechanisms of actions
Parkinson's and research in neurodegeneration

Presynatic regulation of neurotransmitter release (dopamine and glutamate)

 

Sames, D*, Dunn, M. Karpowicz, R., Sulzer, D* (2013)
Visualizing neurotransmitter secretion at individual synapses.  
ACS Chemical Neurotransmission, 4:648-51.

Karpowicz RJ Jr, Dunn M, Sulzer D*, Sames D*. (2013).
APP+, a fluorescent analog of the neurotoxin MPP+, is a marker of catecholamine neurons in brain tissue, but not a fluorescent false neurotransmitter.

ACS Chemical Neurotranmission, 4:858-69.

Gang Hu, Adam Henke, Richard J. Karpowicz, Mark S. Sonders, Frances Farrimond, Robert Edwards, David Sulzer*, Dalibor Sames*(2013)
New fluorescent substrate enables quantitative and high-throughput examination of Vesicular Monoamine Transporter 2 (VMAT2) Function and Inhibition.
JACS, 8:1947-1954. PMID 23859623.

Yvonne Schmitz, Candace Barnard, Jose Lizardi-Ortiz, Ana Mrejeru, Zoe Klein, Craig Lindsley, David Sulzer  (2013).
Glycine transporter 1 inhibition promotes nigrostriatal axon sprouting via NMDA receptors in dopamine neurons.
Journal of Neuroscience, 33:16778-89. PMID: 24133278.

Rodriguez PC, Pereira DB, Borgkvist A, Wong MY, Barnard C, Sonders MS, Zhang H, Sames D, Sulzer D.
Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain.
Proc Natl Acad Sci U S A. 2013 110:870-5. PMID:23277566

Wong, M., Sulzer, D., Bamford, N.
Imaging presynaptic exocytosis in corticostriatal slices.
Methods in Molecular Biology 2011 793:363-376. pdf

Hnasko TS, Chuhma N, Zhang H, Goh GY, Sulzer D, Palmiter RD, Rayport S, Edwards RH.
Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo.
Neuron. 2010 Mar 11;65(5):643-56.PMID: 20223200 pdf

Bendor J, Lizardi-Ortiz JE, Westphalen RI, Brandstetter M, Hemmings HC Jr, Sulzer D, Flajolet M, Greengard P.
AGAP1/AP-3-dependent endocytic recycling of M(5) muscarinic receptors promotes dopamine release.
EMBO J. 2010 Jul 27. pdf

Lee M, Gubernator NG, Sulzer D, Sames D.
Development of pH-responsive fluorescent false neurotransmitters.
J Am Chem Soc. 2010 Jul 7;132(26):8828-30. pdf supplemental materials

Gubernator NG, Zhang H, Staal RG, Mosharov EV, Pereira DB, Yue M, Balsanek V, Vadola PA, Mukherjee B, Edwards RH, Sulzer D, Sames D.
Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals.
Science. 2009 324:1441-4 pdf and supplementary materials

Schmitz, Y., Luccarelli, J., Kim, M., Wang, M., Sulzer, D.
Glutamate controls growth rate and branching of dopaminergic axons.
Journal of Neuroscience, 2009 29:11973-81 pdf

Lyon GJ, Abi-Dargham A, Moore H, Lieberman JA, Javitch JA, Sulzer D.
Presynaptic Regulation of Dopamine Transmission in Schizophrenia.
Schizophr Bull. 2009 pdf

Bamford NS, Zhang H, Joyce JA, Scarlis CA, Hanan W, Wu NP, André VM, Cohen R, Cepeda C, Levine MS, Harleton E, Sulzer D.
Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration.
Neuron. 2008 58:89-103. pdf

here is a commentary on the above paper by Jeremey Day and Regina Carelli in Neuron

Staal RG, Hananiya A, Sulzer D.
PKC theta activity maintains normal quantal size in chromaffin cells.
J Neurochem. 2008 pdf

Markov D, Mosharov EV, Setlik W, Gershon MD, Sulzer D.
Secretory vesicle rebound hyperacidification and increased quantal size resulting from prolonged methamphetamine exposure.
J Neurochem. 2008 pdf

Larsen KE, Schmitz Y, Troyer MD, Mosharov E, Dietrich P, Quazi AZ, Savalle M, Nemani V, Chaudhry FA, Edwards RH, Stefanis L, Sulzer D.
alpha-Synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis.
Journal of Neuroscience 2006 26:11915-11922 pdf

here is a commentary by Aaron Gitler and James Shorter in the Journal of Neuroscience

Mosharov, E., and Sulzer, D.
Detailed algorithms for detection and analysis of exocytic events recorded by amperometry.
Nature Methods 2005 2:651-658. pdf
article supplement

Giraudo, C.G., Hu, C., You, D. Slovic, A.M., Mosharov, E., Sulzer, D., Melia, T.J., Rothman, J.E.
SNAREs can promote complete fusion and hemifusion as alternative outcomes.
Journal of Cell Biology, 2005, 170:249-260 pdf

Staal, R.G.W., Mosharov, E.V., Sulzer, D.
Dopamine neurons release transmitter via a flickering fusion pore
Nature Neuroscience 2004 7:341-346 pdf

here is a commentary on the above paper by Mark Wightman

Bamford, N.S., Zhang, H., Schmitz, Y., N.P. Wu, Cepdea, C., Levine, M.S., Schmauss, C., Zakharenko, S.S., Zablow, L., Sulzer, D.
Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
Neuron 2004 42, 653-663 pdf

here is a commentary on the above paper by Fu-Ming Zhou and John Dani in Neuron

Zhang, H., and Sulzer, D.
Frequency-dependent modulation of dopamine release by nicotine
Nature Neuroscience, 2004 7, 581-582 pdf

here is an article on the above paper, including related studies and sociocultural analysis from Nature Medicine

Hui Zhang and David Sulzer
Glutamate spillover in the striatum depresses dopaminergic transmission by activating Group I metabotropic glutamate receptors
Journal of Neuroscience 2003 23:10585-10592 pdf

Eugene V. Mosharov, Liang-Wei Gong, Bhavanna Khanna, David Sulzer, and Manfred Lindau
Intracellular patch electrochemistry: regulation of cytosolic catecholamines in chromaffin cells
Journal of Neuroscience 2003 23:5835-5845 pdf

Yvonne Schmitz,Marianne Benoit-Marand, Francois Gonon, and David Sulzer
Presynaptic regulation of dopaminergic neurotransmission (Review)
Journal of Neurochemistry, 2003 87:273-289 pdf

Schmitz, Y., Schmauss, C., and Sulzer, D.
Altered dopamine release and uptake in mice lacking D2 receptors
Journal of Neuroscience 2002 15:8002-2009 pdf

Pothos, E., Mosharov, E., Liu, K.P., Setlik, W., Baldini, G., Gershon, M.D., Tamir, H., Sulzer, D
Stimulation-dependent regulation of secretory vesicle pH, volume, and quantal size

Journal of Physiology 2002 542:453-476 pdf

David Sulzer and Emmanuel N Pothos
Presynaptic mechanisms that regulate quantal size (Review)
Reviews in the Neurosciences 2000 11:150-212 pdf

Pothos, E., Larsen, K., Liu, Y.J. Edwards, R.H., and Sulzer, D.,
Synaptic vesicle transporter expression regulates vesicle phenotype and quantal size

Journal of Neuroscience 2000 20:7297- 7308 pdf

Abelovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W.-H., Verdugo, J.M.G., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., Rosenthal, A.
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
Neuron, 2000 25:239-252 pdf

Colliver, T., Hess, E., Pothos, E.N., Sulzer, D., and Ewing, A.G.
Quantitative and statistical analysis of the shape of amperometric spikes recorded from two populations of cells
Journal of Neurochemistry, 2000 74:1086-1097 pdf

David Sulzer and Robert Edwards
Vesicles: equal in neurotransmitter concentration but not in volume
(Commentary)
Neuron, 2000 28: 5-7 pdf

Emmanuel N Pothos, Serge Przedborski, Viviana Davila, Yvonne Schmitz, and David Sulzer
D2-Like Dopamine Autoreceptor Activation Reduces Quantal Size in PC12 Cells
Journal of Neuroscience, 1998 18: 5575-5585 pdf

David Sulzer, Myra P Joyce, Ling Lin, Daron Geldwert, Suzanne N Haber, Toshiaki Hattori, and Stephen Rayport
Dopamine Neurons Make Glutamatergic Synapses In Vitro
Journal of Neuroscience, 1998 18: 4588-4602 pdf

Emmanuel N Pothos, Viviana Davila, and David Sulzer
P
resynaptic Recording of Quanta from Midbrain Dopamine Neurons and Modulation of the Quantal Size
Journal of Neuroscience, 1998 18: 4106-4118 pdf

 

Physiology of midbrain dopamine neurons

Yvonne Schmitz, Candace Barnard, Jose Lizardi-Ortiz, Ana Mrejeru, Zoe Klein, Craig Lindsley, David Sulzer  (2013).
Glycine transporter 1 inhibition promotes nigrostriatal axon sprouting via NMDA receptors in dopamine neurons.
Journal of Neuroscience, 33:16778-89. PMID: 24133278.

Torres CA, Sulzer D.
Macroautophagy can press a brake on presynaptic neurotransmission
Autophagy. 2012 8:1540-1.PMID:22767262

Anzalone A, Lizardi-Ortiz JE, Ramos M, De Mei C, Hopf FW, Iaccarino C, Halbout B, Jacobsen J, Kinoshita C, Welter M, Caron MG, Bonci A, Sulzer D, Borrelli E.
Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors.
J Neurosci. 2012 32:9023-34. PMID:22745501
Free Article

Zhang H, Sulzer D.
Regulation of striatal dopamine release by presynaptic auto- and heteroreceptors.
Basal Ganglia. 2012 Mar 1;2(1):5-13. PMID:22712055
Free PMC Article

Pereira DB, Sulzer D.
Mechanisms of dopamine quantal size regulation.
Front Biosci. 2012 Jun 1;17:2740-67. Review. PMID:22652810

Hernandez D, Torres CA, Setlik W, Cebrián C, Mosharov EV, Tang G, Cheng HC, Kholodilov N, Yarygina O, Burke RE, Gershon M, Sulzer D.
Regulation of presynaptic neurotransmission by macroautophagy.
Neuron. 2012 74(2):277-84.
PMID:22542182

Schmitz, Y., Luccarelli, J., Kim, M., Wang, M., Sulzer, D.
Glutamate controls growth rate and branching of dopaminergic axons.
Journal of Neuroscience, 2009 29:11973-81 pdf

Chuhma,N., Zhang, H., Mustine, J., Sulzer, D., Hen, R., Rayport, S.G.
Dopamine neurons mediate a fast excitatory signal via glutamatergic neurotransmission.
Journal of Neuroscience, 2004 24:972-981. pdf

Viviana Davila, Zhen Yan, Liviu C. Craciun, Diomedes Logothetis, and David Sulzer
D3 Dopamine Autoreceptors Do Not Activate G-Protein-Gated Inwardly Rectifying Potassium Channel Currents in Substantia Nigra Dopamine Neurons
Journal of Neuroscience, 2003, 23:5693-5697 pdf

David Sulzer and Aurelio Galli
Transporter currents are promoted from curiosity to physiology (Review)
Trends in Neuroscience, 2003 26: 173-6 pdf

David Sulzer and Stephen Rayport
Dale's principle and glutamate corelease from ventral dopamine neurons (Review)
Amino Acids 2000, 19:45-52 pdf

David Sulzer, Myra P Joyce, Ling Lin, Daron Geldwert, Suzanne N Haber, Toshiaki Hattori, and Stephen Rayport
Dopamine Neurons Make Glutamatergic Synapses In Vitro
Journal of Neuroscience, 1998 18: 4588-4602 pdf

Rayport, S., and Sulzer, D.
Visualization of antipsychotic binding to living mesolimbic neurons reveals D2 receptor, acidotropic, and lipophilic components
Journal of Neurochemistry,1995 65: 691-703 pdf

Stephen Rayport, David Sulzer, Wei-Xi Shi, Saswana Sawasdikosol, Jacqueline Monaco, Diedre Batson, and Geetha Rajendran
Identified postnatal mesolimbic dopamine neurons in culture: morphology and electrophysiology
Journal of Neuroscience, 1992 12: 4264-4280 pdf

Psychostimulant and addictive drugs: mechanisms of action

Sulzer D.
How addictive drugs disrupt presynaptic dopamine neurotransmission.
Neuron. 2011 69:628-649. pdf

Markov D, Mosharov EV, Setlik W, Gershon MD, Sulzer D.
Secretory vesicle rebound hyperacidification and increased quantal size resulting from prolonged methamphetamine exposure
J Neurochem. 2008 107:1709-21. pdf

Tallóczy Z, Martinez J, Joset D, Ray Y, Gácser A, Toussi S, Mizushima N, Nosanchuk J, Goldstein H, Loike J, Sulzer D, Santambrogio L.
Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis.
PLoS Pathog. 2008 Feb 15;4:e28 pdf

David Sulzer, Mark Sonders, Nathan W. Poulsen, and Aurelio Galli
Mechanisms of neurotransmitter release by amphetamines: a review
Progress in Neurobiology, 2005 75:406-433. pdf

Eugene V. Mosharov, Liang-Wei Gong, Bhavanna Khanna, David Sulzer, and Manfred Lindau
Intracellular patch electrochemistry: regulation of cytosolic catecholamines in chromaffin cells
Journal of Neuroscience, 2003 23:5835-5845 pdf

Kristin Larsen, Edward Fon, Terry G. Hastings, Robert H. Edward, R.H., and David Sulzer
Methamphetamine -induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis
Journal of Neuroscience, 2002 22:8951-8960 pdf

Yvonne Schmitz, C. Justin Lee, Claudia Schmauss, Francois Gonon, and David Sulzer
Amphetamine distorts synaptic dopamine overflow: effects on vesicular stores, D2 autoreceptors, and uptake
Journal of Neuroscience, 2001 21: 5916-5924 pdf

Edward Fon, Emmanuel N Pothos, Bao-Cun Sun, Nigel Killeen, David Sulzer and Robert H Edwards
Vesicular transport regulates monoamine storage and release but Is not essential for amphetamine action
Neuron, 199719: 1271-1283. pdf

David Sulzer, Ta-Kung Chen, Yau-Yi Lau, Helle Kristensen, Stephen Rayport, and Andrew Ewing
Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport
Journal of Neuroscience, 1995 15: 4102-4108 pdf

Joseph F Cubells, Stephen Rayport, Geetha Rajendran, and David Sulzer
Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress
Journal of Neuroscience, 1994 14: 2260-2271 pdf

David Sulzer and Stephen Rayport
Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action
Neuron, 1990 5: 797-808 pdf

Parkinson's, Huntington's, Autism, and research in neurodegeneration

Yvonne Schmitz, Candace Barnard, Jose Lizardi-Ortiz, Ana Mrejeru, Zoe Klein, Craig Lindsley, David Sulzer  (2013).
Glycine transporter 1 inhibition promotes nigrostriatal axon sprouting via NMDA receptors in dopamine neurons.
Journal of Neuroscience, 33:16778-89. PMID: 24133278.

Sulzer D, Surmeier DJ.
Neuronal vulnerability, pathogenesis, and Parkinson's disease
Mov Disord. 2013 Apr 15. doi: 10.1002/mds.25187. PMID:23589357

Kuo SH, Tang G, Louis ED, Ma K, Babji R, Balatbat M, Cortes E, Vonsattel JP, Yamamoto A, Sulzer D, Faust PL.
Lingo-1 expression is increased in essential tremor cerebellum and is present in the basket cell pinceau.
Acta Neuropathol. 20137PMID:23543187

Orenstein SJ, Kuo SH, Tasset I, Arias E, Koga H, Fernandez-Carasa I, Cortes E, Honig LS, Dauer W, Consiglio A, Raya A, Sulzer D, Cuervo AM.
Interplay of LRRK2 with chaperone-mediated autophagy.
Nat Neurosci. 2013 Apr;16(4):394-406. PMID:23455607

Tang G, Gutierrez Rios P, Kuo SH, Akman HO, Rosoklija G, Tanji K, Dwork A, Schon EA, Dimauro S, Goldman J, Sulzer D.
Mitochondrial abnormalities in temporal lobe of autistic brain.
Neurobiol Dis. 2013 Jun;54:349-61. PMID:23333625

Surmeier DJ, Sulzer D.
The pathology roadmap in Parkinson disease.
Prion. 2013 Jan-Feb;7(1):85-91.

Kuo SH, Tang G, Ma K, Babij R, Cortes E, Vonsattel JP, Faust PL, Sulzer D, Louis ED.
Macroautophagy abnormality in essential tremor.
PLoS One. 2012;7(12):e53040. PMID:23300858

Sulzer D, Surmeier DJ.
Neuronal vulnerability, pathogenesis, and Parkinson's disease.
Mov Disord. 2013 Jan;28(1):41-50. PMID:22791686

Koga H, Martinez-Vicente M, Arias E, Kaushik S, Sulzer D, Cuervo AM.
Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease.
J Neurosci. 2011 Dec 14;31(50):18492-505. PMID:22171050

Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, Kaushik S, de Vries R, Arias E, Harris S, Sulzer D, Cuervo AM.
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.
Nat Neurosci. 2010 May;13(5):567-76. PMID: 20383138 pdf

Sulzer D.
Clues to how alpha-synuclein damages neurons in Parkinson's disease.
Mov Disord. 2010;25 Suppl 1:S27-31.PMID: 20187229 pdf

Zhang W, Phillips K, Wielgus AR, Liu J, Albertini A, Zucca FA, Faust R, Qian SY, Miller DS, Chignell CF, Wilson B, Jackson-Lewis V, Przedborski S, Joset D, Loike J, Hong JS, Sulzer D, Zecca L.
Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson's Disease.
Neurotox Res. 2009 pdf

Mosharov EV, Larsen KE, Kanter E, Phillips KA, Wilson K, Schmitz Y, Krantz DE, Kobayashi K, Edwards RH, Sulzer D.
Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons.
Neuron. 2009 62:218-29 pdf and supplemental material

here is a commentary on the above paper by James Surmeier in Neuron

Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV, Hodara R, Fredenburg R, Wu DC, Follenzi A, Dauer W, Przedborski S, Ischiropoulos H, Lansbury PT, Sulzer D, Cuervo AM.
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
Journal Clinical Investigation 2008 118: 777-788 pdf

Sulzer D, Mosharov E, Talloczy Z, Zucca FA, Simon JD, Zecca L.
Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
J Neurochem. 2008 106:24-36 pdf

Tang G, Yue Z, Talloczy Z, Hagemann T, Cho W, Messing A, Sulzer DL, Goldman JE.
Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways
Hum Mol Genet. 2008 17:1540-55 pdf

Sulzer, D.
Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease
Trends in Neuroscience 2007 30:244-250 pdf
article supplement

Sulzer, D., Schmitz, Y.
Parkinson's disease: return of an old prime suspect (commentary)
Neuron 2007 55:8-10 pdf

Mosharov, E., Staal, R.G.W., Bov, J., Hananiya, A., Markov, D., Poulsen, N., Larsen, K.E., Troyer, M.D., Edwards, R.H., Przedborski, S., Sulzer, D.
Alpha-synuclein overexpression permeabilizes secretory vesicles and increases cytosolic catecholamine
Journal of Neuroscience 2006 26:9304-9311 pdf

Ana Maria Cuervo, Leo Stefanis, Ross Fredenburg, Peter Lansbury, David Sulzer
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
Science 2004 305:1292-5 pdf

Stan Fahn and David Sulzer
Neurodegeneration and neuroprotection in Parkinson's Disease (review)
NeuroRx 2004 1:139-154 pdf

Luigi Zecca, Fabio Zucca, Henrik Wilms and David Sulzer
Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics
TRENDS in Neurosciences, 2003, 26:216-220 pdf

Larsen, K., and Sulzer, D.
Autophagy in neurons: a review
Histology & Histopathology, 2002, 17:897-908
pdf

Luigi Zecca, Ruggero Fariello, Peter Riederer, David Sulzer, Alberto Gatti, Davide Tampellini
The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease
FEBS Letters, 2002, 510: 216-220 pdf

Dauer, W., Kholodilov, N., Vila, M., Trillat, A.C., Goodchild, R., Larsen, K., Staal, R., Tieu, K., Schmitz, Y., Yuan, C.A., Rocha, B., Jackson-Lewis, V.J., Hersch, S., Sulzer, D., Przedborski, S., Burke, R., Hen, R.
Resistance of alpha-synuclein null mice to the Parkinsonian neurotoxin MPTP
Proc Natl Acad Sci USA,2002 99:14524-14529. pdf

David Sulzer
Alpha-synuclein and cytosolic dopamine; stabilizing a bad situation (Commentary)
Nature Medicine, 2001, 12: 1280-1282 pdf

Stefanis, L., Larsen, K.E., Rideout, H.J., Sulzer, D., and Greene, L.A.
Expression of A53T mutant, but not wild type, alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
Journal of Neuroscience, 2001 21, 9549-9560
pdf

Petersen, A., Behr, G.G., Larsen, K., Romero, N., Przedborski, S., Brundin, P., Sulzer, D.
An expanded CAG repeat in exon 1 of the Huntington's Disease gene promotes dopamine-mediated autophagy and death in striatal neurons
Hum. Mol. Genet., 2001 10:1243-54 pdf

Zecca, L., Tampellini, D., Gerlach, M., Riederer, P., Fariello, R.G., and Sulzer, D. (2001)
Substantia nigra neuromelanin: structure, synthesis and molecular behaviour
(Review)
J. Clinical Pathol. 2001 54:414-418 pdf

Sulzer, D., Bogulavsky, J., Larsen, K.E., Karatekin, E., Kleinman, M., Turro, N., Kranz, D., Edwards, R., Greene, L.A., Zecca, L.
Neuromelanin synthesis sequesters cytosolic catecholamines not accumulated by synaptic vesicles
Proc Natl Acad Sci USA, 2000 97:11869-11874. pdf

Abelovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W.-H., Verdugo, J.M.G., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., Rosenthal, A.
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
Neuron, 2000 25:239-252. pdf

David Sulzer and Luigi Zecca
Intraneuronal dopamine-quinone biosynthesis: a review
Neurotoxicity Research, 2000 1:181-195 pdf

Kholidov, N.G., Neystat, M., Oo, T.F., Larsen, K.E., Sulzer, D., and Burke, R.E.
Increased expression of rat synuclein 1 in the substantia nigra compacta identified by mRNA differential display in a model of developmental target injury
Journal of Neurochemistry, 1999: 73:2586-2599. pdf

Mena, M.A., Davila, V., Bogaluvsky, J., and Sulzer, D.
L-DOPA potentiates NGF-induced outgrowth and quantal dopamine release in PC12 neurites.
Molecular Pharmacol., 1998 54:678-686. pdf

Robert E Burke, Megan Antonelli, and David Sulzer
Glial Cell Line-Derived Neurotrophic Growth Factor Inhibits Apoptotic Death of Postnatal Substantia Nigra Dopamine Neurons in Primary Culture
Journal of Neurochemistry, 1998 71, 517-525. pdf

Maria Angeles Mena, Viviana Davila, and David Sulzer
Neurotrophic Effects of L-DOPA in Postnatal Midbrain Dopamine Neuron/Cortical Astrocyte Cocultures
Journal of Neurochemistry, 1997 69, 1398-1408. pdf

Serge Przedborski, Uzma Khan, Vladimir Kostic, Elaine Carlson, Charles J Epstein, and David Sulzer
Increased Superoxide Dismutase Activity Improves Survival of Cultured Postnatal Midbrain Neurons
Journal of Neurochemistry, 1996, 67, 1383-1392 pdf


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